Alex O'Hirn was a nerdy student at Midtown High School who seemed to have everything against him. In addition to being constantly picked on by Flash Thompson, the school bully, he lost an internship at OsCorp to Peter Parker. Sometime after, Alex somehow got his hands onto one of Doctor Octopus' samples of mutagenic animal DNA. O'Hirn ingested the sample to become the monstrous Rhino, and sought his revenge on Thompson
Rhino then trashed Flash's car and tracked him down to his home. Spider-Man and Power Man were barely able to stop the rampaging monster, and O'Hirn was taken into S.H.I.E.L.D.custody. Before he was taken away, however, Flash apologized for the years he bullied him.
Return of the Sinister Six
An armored Doctor Octopus and Lizard invades Ryker's Islandand reassembles the Sinister Six by armoring up Electro, Kraven the Hunter, Rhino, and Scorpion. The Sinister Six give Spider-Man a hard time until Norman Osborn in the Iron Patriot armor and the rest of Spider-Man's team arrives. While Spider-Man fights Lizard, Iron Patriot fights Doctor Octopus while Spider-Man's team fight the other members of the Sinister Six. When the Sinister Six end up combining their attacks to take down Iron Patriot, Doctor Octopus plans to inject Spider-Man with the Goblin Serum. Doctor Octopus then injects Norman Osborn with the Goblin serum while Spider-Man restored Lizard to Dr. Curt Connors. Norman Osborn becomes Green Goblin where he defeats Rhino and Octopus. Though Spider-Man has won against the Sinister Six, Green Goblin gets away with the captive members of Spider-Man's team. After the Sinister Six were defeated, Dr. Curt Connors thanks Spider-Man for saving him.
Spidey and Hulk are the last line of defense when a bitter battle between Agent Venom and Rhino threatens to destroy New York City. Spider-Man and Hulk are eventually able to reason with Rhino. Causing him to give up his evil ways and join S.H.I.E.L.D. Academy.