In this universe, Bruce Banner is said to have shared space with a gamma explosion and somehow survived, resulting in his ability to transform into a rampant grey-green-skinned creature when he becomes angry. He is kept on medication to stop him turning into the Hulk again, having once destroyed part of New York City when he transformed. The medication makes him depressed and he is convinced it's slowing his work down. Replacing Hank Pym as head of the super soldier program, he desperately wishes to recreate the Captain America serum to give him control over the Hulk. Betty Ross is his ex-girlfriend and assistant.
Bruce briefly has control over the Hulk when he mixes his blood with Captain America's serum, aiding him during the Chitauri attack. However, as the violence intensifies, he becomes savage once more and turns on the Avengers. Proving to be stronger than even Thor, it takes Betty Ross to calm the Hulk down long enough for a sedative to take affect. Bruce is kept in a glass prison and gassed with sedative to avoid him getting too excited.
Banner is tormented by a disgruntled ex-worker of his who acts as his interrogator. Bruce realises that the Chitauri's exposure the gamma the Hulk radiates let their vibranium technology to become brittle and fall apart. The Chitauri seemingly kill Bruce with gas poisoning, but he eventually becomes the Hulk and attacks Chitauri invaders before escaping, looking at Betty for one last time.