Dr. Heinz Doofenshmirtz (voiced by Dan Povenmire) is a mad scientist appearing in all but one episode's B-Plots thus far. He is the father to teenage Vanessa Doofenshmirtzand is the head of his own company, Doofenshmirtz Evil Inc. Depending on the episode, Dr. Doofenshmirtz's main goal is to either destroy or rule the Tri-State Area which was suggested to him as a starting point before trying to take over the world. Routinely bumbling, incompetent, and forgetful, almost all of Doofenshmirtz's plans—always involving various gadgets and inventions—have been thwarted by Perry the Platypus, though a few were quite successful in nature, such as in the 2014 special "Phineas and Ferb Save Summer" when Doofenshmirtz succeeded in moving the Earth away from its original orbit, much to Perry's dismay. After most defeats, he shouts his catchphrase, "Curse you, Perry the Platypus!" His first invention as a child was simply called "Inator" which led to his modern contraptions usually ending with the suffix of the same name.
Throughout the series, Doofenshmirtz's flashbacks (which are often shown after Perry has been captured) explore his mentally abusive and lonely childhood growing up in the fictional village Gimmelshtump, Druelselstein. Before becoming an evil scientist, Doofenshmirtz was a bratwurst vendor until being put out of business by the hot dog industry. Doofenshmirtz usually monologues and displays acts of cartoon-style physical violence towards his nemesis Perry, a skilled anthropomorphic platypus secret agent. Doofenshmirtz appears in several merchandise pieces, particularly the book series,and the video game.
In the 2011 TV film, Phineas and Ferb the Movie: Across the 2nd Dimension, an alternate reality (yet more intelligent and successful) version of Dr. Doofenshmirtz appears as the main antagonist, with the regular Doctor Doofenshmirtz serving as a supporting character. 2nd Doofenshmirtz later returns in the episode sequel, Tales from the Resistance: Back to the 2nd Dimension, as one of the main antagonists (the other is his wife 2nd Charlene).
"I'm not very... How do the kids say it these days... Handsome."
— Doofenshmirtz to Perry
"Speaking of wishes, you know what I never understood? Genies! They tell you to wish for anything you want and then they add some terrible twist. Like you wish to jump high so he turns you into a frog. Why? Who gains from this? The genie? Where's the benefit? You should be fighting genies, man, not me. I'm not the problem; genies are the problem."
— Doofenshmirtz rambles on to Perry the Platypus
"Curse you, Perry the Platypus!"
— Heinz Doofenshmirtz
"It occurs to me that though I've never had a son, there is someone I can always count on to be there, someone I've begun to think of as family."
— Doofenshmirtz about Perry the Platypus
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