Monkey Brains: When Dr. Falco reported Rockwell missing on the news, Donatello and April O' Neil investigate his disappearance hoping to find clues about the The Kraang. While in his abandoned lab, they encounter Dr. Falco, who tells them that Rockwell had been using mutagen to experiment on monkeys. Donatello also takes a flash drive from the lab containing data on Rockwell's research. The mutant monkey confronts them later. He attacks and defeats Donatello easily, and is about to harm April but calms down when she talks to him and runs away. April and the Turtles later search the city for the mutant chimp. Once they capture him, April realizes that the chimp is Dr. Rockwell. They return him to Falco, who promises to take care of him. But later, while studying Rockwell's flashdrive, Donatello learns that Falco has lied to them about Rockwell in order to get a neurologic mutagen from him in order to give himself psychic abilities.
Mazes & Mutants: The Turtles fought Monkey Goblins who resembled Tyler Rockwell.
Metalhead Rewired: Tyler is seen as a brief cameo as one of the many mutants captured by the Kraang.
Battle for New York: Alongside Slash, Pigeon Pete, andLeatherhead, Rockwell is recruited by Jack Kurtzman to repel the Kraang invasion following the absence of the Ninja Turtles. Forming the Mighty Mutanimals, the four mutants dedicate themselves to fighting the Kraang, where Rockwell is the team's brains.
Clash of the Mutanimals: He gets mind controlled by the Mind-Worms along with Slash.
Dinosaurs Seen in Sewers!:
Annihilation Earth: He fights the Triceraton warriors in Washington Square Park along with the Ninja Turtles. He is trapped by a Triceraton alien.
- Whenever Tyler gets mad. his eyes bug out. This is a reference to the old cymbal-banging monkey toy.