As Chancellor Sheppard arrived at Duel Academy after it had vanished into the alternate dimension, she attempted to kidnap him to use him as hostage, but Maximillion Pegasus arrived in a helicopter and his men restrained her.
When Maximillion Pegasus was creating the "Rainbow Dragon" card, Echo threatened to blow up the tablet and everyone around it to prevent Adrian from returning, but Pegasus' men restrained her.
When Jaden Yuki and his companions open the portal to the third alternate dimension in search of Jesse Anderson, she and Dr. Crowler get sucked in as well, having been nearby. She later meets up Aster Phoenix and Zane Truesdale only for Adrian, now zealous on fulfilling his ambition, to show up as well. During Adrian and Aster's Duel, Echo is willingly sacrificed by Adrian to the spirit of "Exodia the Forbidden One" to make it his servant. Despite this, her spirit still loved him. Her spirit later aids Adrian in his Duel against Jesse when he's possessed by Yubel, but only ends being used by Yubel to recover its power when the psychopath absorbs the darkness in her soul. Adrian and Echo are the only characters who died in the alternate dimension that were not stated to return.