Future Vegeta's life was exactly the same as his main timeline counterpart's life until August of Age 764 when Future Goku used the Instant Transmission to arrive on Earth and kill Future Frieza and Future King Cold. Sometime afterward, Vegeta trained and became a Super Saiyan.
In Age 766, Future Goku had been stricken down by a deadly Heart Virus that had no cure. Future Vegeta, along with the other Z Fighters and company await the news of Future Goku's health. However, Future Goku passes away, leaving Future Vegeta shocked about Future Goku's death and finds himself very upset due to the fact that he will never get his chance to defeat his rival in battle.
Six months later on May 12th, Age 767, the Androids attack and Future Vegeta is the second Z Fighter to be killed by them. In the TV special, Vegeta is shown receiving a hard kick to the stomach by Future Android 17, and in the episode "Ghosts from Tomorrow" it is shown during a flashback that he dies after being struck by 17's Photon Flash while stuck in the ground after receiving a brutal attack. In both instances, he retains his Super Saiyan power and abilities.
Future Vegeta was 35 years old when he was killed by the Androids.
- In Future Trunks' flashback, he claimed that Future Vegeta was the first to die at the hands of Androids 17 and 18, and Future Piccolo was the second. However, in The History of Trunks, it was said Future Piccolo was the first to die and Future Vegeta was the second.
- In a what-if in the video game Dragon Ball Z: Supersonic Warriors 2, Vegeta is the one who destroys the Androids and larval Cell.