Washington's head carving is seen on Mount Rushmore in "North by North Quahog". For the episode, the heads of Mt. Rushmore can talk.
When Peter tries to talk Chip out of a day of adventure because it would be tiring for him in "Vestigial Peter", he insists he is just being honest like George Washington. A cutaway shows young George owning up to chopping down a cherry tree, but effeminately disavows any knowledge of a pamphlet on the Boston Tea Party his father finds under his bed. George is voiced by Seth Green in this appearance.
Mount Rushmore is mentioned again in a cutaway mocking North Dakota in "Baking Bad".
In "Stewie, Chris & Brian's Excellent Adventure", he is observed crossing the Delaware with water wings due to being terrified of the water.
He is voiced by Seth MacFarlane.