Agents Leo Fitz and Jemma Simmons were called in by S.H.I.E.L.D. to assist in repairs and upgrades for the Triskelion base. During a training session for the S.H.I.E.L.D. Trainees, one of the robots malfunctioned and attacked Spider-Man with lethal force. The attack ended when Rhino bashed it. Fitz later tried to examine the remains, but its central processor has been destroyed by Rhino's attack.
Spider-Man and Iron Spider later questioned the two scientists about the malfunction and suggested possible sabotage. They explained that the robots were moved directly to the training area from the S.H.I.E.L.D. factory by the students and calibrated by Dr. Curt Connors. After Dr. Connors was turned back into the Lizard and began infecting everyone he could sink his teeth into, Fitz and Simmons escaped through the floor vents and met with Spider-Man and Iron Spider who had one vial of Lizard cure. They attempted to synthesize the cure for mass distribution, but the infected lizards broke in via Cloak's teleportation and damaged the equipment before infecting them as well. The pair were eventually cured, along with everyone else in the building, when Spider-Man used their Aerosol Dispersal Unit to pump the cure throughout the ventilation system.