Morbius appeared in Spider-Man: The Animated Series voiced by Nick Jameson. Morbius first appeared in his human form in "The Insidious Six" (Season #2, episode 1) and the episode that followed his debut, "Battle of the Insidious Six." In these episodes, Morbius has a romance with Felicia Hardy (who would later become the Black Cat). In the episode titled "Morbius," he stole a vial of Peter Parker's blood in the belief this was part of Parker's entry in a science competition they were both competing in. While examining the blood in his laboratory, one of the vampire bats he was experimenting on escaped, and began to lap it up. When Morbius tried to scare the bat away, it bit him. The bite infected him with Parker's irradiated blood, transforming him into a living vampire. He appeared as a villain in the following four episodes: "Enter the Punisher," "Duel of the Hunters," "Blade the Vampire Hunter," and "The Immortal Vampire." The episode "Blade The Vampire Hunter" revealed that this incarnation of the character was vulnerable to garlic and garlic-enhanced weaponry. Blade uses garlic gas grenades against him and Spider-Man uses similar garlic based oils in his webbing, which hurt and nearly restrain Morbius. At the end of "The Immortal Vampire," Felicia manages to appeal to Morbius' humanity, and Morbius redeems himself at the end of this episode. Later Morbius appears in the episodes "The Awakening" and "The Vampire Queen" in Season #4. At the end of "The Vampire Queen," Morbius joins forces with vampire hunter Blade and Black Cat to stop Blade's evil mother, Mirium. This episode reveals that Morbius has a psychic link to the more conventionally created supernatural vampires such as Miruam. Morbius made a cameo at the beginning and end of the tenth episode of the animated version of "Secret Wars," along with Blade, who were not only concerned about stopping Mirium but curious where the Black Cat had gone. (She had been transported from Earth to the Secret Wars planet to fight alongside Spider-Man.) That was the last appearance of Morbius in the show. Fundamental changes were enforced upon his depiction by Fox, who imposed a heavy level of censorship on the series. These changes include being unable to bite anyone, despite having fangs and clearly being a vampire. Instead he was rendered with suckers on his palms to drain his victims, similar to another "Living Vampire" from the Marvel Universe, Bloodscream. The word 'blood' was not allowed to be used in any capacity, and was replaced with 'plasma'.

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