She was a member of Konohagakure's Uchiha clan.
With both of her grandson's parents dead, she became Obito's guardian. On the day of the Youth Ninja Competition, she answered her apartment door when Rin Nohara arrived, and teased Obito about having a great grand child. Later that night at dinner, Obito asked her which of his parents he took after. She responded that he takes after both of them and that he must honour them and work for the sake of others.
A kind woman, she cared very much for her grandson, telling him how much he was like both his parents and wanted to see him lead a bright future. Also seemingly aware of Obito's crush on Rin, she was not above teasing him about the prospect of him giving her future great-grandchildren, despite Obito being only five years old at the time.
She was an elderly woman with shoulder-length grey hair and large black eyes. She wears a high-collared purple outfit with a brow vest emblazoned with the Uchiha's crest.