Zekrom appeared in Black—Victini and Reshiram and White—Victini and Zekrom. In the former, it is controlled by Damon, while in the latter, it is controlled by Ash. Along with Reshiram, Zekrom can speak through telepathy.
A Zekrom made its debut in a cameo in the opening of In The Shadow of Zekrom!. It made its full appearance later where it appeared above the skies of Nuvema Town, its huge lightning bolt zapped Pikachu making it unable to use its electricity. It appears again in Enter Iris and Axew!, where Pikachu recovers its electric powers.
Zekrom was mentioned again in A Rival Battle for Club Champ! and The Name's N!. It was also the main subject of Explorers of the Hero's Ruins!, although it does not actually appear.
A Zekrom appears in the second XY Series movie, Hoopa and the Clash of Ages. One hundred years prior to the events of the movie, it was summoned by Hoopa alongside a Reshiram and Regigigas. The three fought Hoopa in Dahara City but were easily defeated and sent back through portals to their original homes.
A Zekrom appeared in a fantasy in Farewell, Unova! Setting Sail for New Adventures!.